Disclaimer: I don't have this setup as I'm waiting for an additional feature.
Check out sk161612 for more information.
This feature allows you to specify a domain (and the subdomains) to allow access to. Let's say a source needs access to *.something.biz and there isn't' a relevant application. You can try to write you own application, but often, that might not be feasible (think non-web encrypted traffic). The gateway can watch the DNS requests looking for anything that matches something.biz and store the corresponding IPs in its cache. This way when the rule in question is evaluated, the gateway can check the cache and allow/deny access.
A domain object won't work here because reverse DNS doesn't exist or doesn't match the site.
An FQDN domain object won't work here because you don't know all the FQDNs that will be called.
Make sense?