The default 'Recently Viewed' list on the home screen is ok, the entries on the list are readable, and you can find the one you want easily. On the other hand, The 'All Open Service Requests' view is a bit of a mess, with most of the fields truncated to the point that they're not that useful. (On further inspection, all except the two 'recently' ones are like this).
On the create new SR page, the UC account dropdown is... odd. It is giving me a choice of three chosen customer UC accounts and 'Other', with no particular idea why those three accounts specifically were chosen? Odd.
Asset dropdown is mostly ok, but might be nice to include the device hostname if available.
The walkthrough video/slideshot thing indicates that the dropdowns should automatically filter based on other information entered, this doesn't seem to be the case in at least some instances - e.g. select R80.20, get offered Splat & Windows as options. (Although maybe it only takes the 'Product Line' bit into account for this, and ignores the version).
There are a few instances as well where a mouseover box causes the underlying page to shift around which is a bit annoying, but not a major problem.
The lack of history within a ticket (as mentioned further up the thread) is probably the biggest problem, especially when picking up tickets from colleagues half way through.