You definitely don't need ISOmorphic for that system. I have a six of them in production, I think. When I set them up, I just fed the ISO image to the LOM's KVMS. It worked beautifully.
As someone learning the system, there are a few things of which you should be aware. Most notably, when you cleanly install a new system like that, it can run with all local features for 15 days with no explicit license. Antivirus, IPS, URL filtering, and a few others require definition updates, which aren't covered by this 15-day "plug-n-play eval". Once this 15 day window is up, you can generate a new eval license in the User Center, or you can just wipe the box and reinstall it.
The software also works very well in VMware Workstation and VirtualBox. I haven't personally tried it in other desktop hypervisors, but I would expect it to work in almost any (maybe not bhyve or vmm). This is nice because Check Point environments rarely involve just one server. Doing it this way rather than directly on hardware, you can test out clustering, management HA, VPNs between multiple firewalls managed by the same management server, and far more.