@gemechis MTA is not required for AntiSpam-Blade. Without MTA you have features like BlackList block, IP reputation and content spam check for messages they are not sent encrypted (mentioned by @PhoneBoy )
ThreatExtraction (SandBoxing, remove malicious content from file-attachments or convert to pdf) requires MTA.
As a hint....All features they must be configured in the old SmartDasboard can be used without MTA. All other configuration in the mail tab of ThreatPrevention-Profile needs MTA enabled.