@Sagar_Manandhar maybee you can provide more details of your use case.
With the shown NAT rules your internal webserver can be reached via the IP address from ISP_A and via the IP address from ISP_B. Both are active at all the time. The return traffic from your webserver will be routed through the same ISP as it coming in. An incoming packet via ISP_A will be forwarded to your webserver and the return packet will be send out via ISP_A. This is how ISP redundancy works.
You have to define both external IPs in the external DNS for name resolution of your webserver. In case one of the ISPs is failing the failing ISPs external IP address has to be removed from this DNS record. If you want to have an automatic change of the DNS records you can use DNS proxy feature of ISP redundancy.
But I would prefer an external solution to check the availability of your ISPs and route the traffoc to the right incoming site. Something like Azure Traffic Manger as an example, they can probe your webserver via both ISPs and change DNS following the availability.