Anti-spoofing is basically a sanity check the gateway performs to ensure traffic is coming from the correct interface based on the source IP or being routed out the correct destination interface based on destination IP.
The settings for anti-spoofing depend on whether the SMB device is centrally managed or not.
For centrally managed gateways, it's set on the gateway object on the relevant interface.
For locally managed devices, it's calculated based on the routing table.
For example, the LAN interface should just be the local subnet plus any subnets for which you have routes where the next hop is on the LAN interface.
The WAN interface is "everything but what I expect to see on other interfaces."
Assuming the traffic is dropped on the LAN interface, is the source IP on the same subnet as the LAN interface? If not, is there an explicit route for that IP or subnet configured in 1450 with a next hop of an IP address on the LAN?