In my experience, depending on log volume, a reboot works and comes back on it's own, does DB cleanup and re-indexes without issue (R80.10 take 462, Smart-1 3050, 2.6.18-92cpx86_64, 64-bit, maxed RAM) within 24 hours.
Sometimes full reporting fidelity can take more time. I'm fully expecting performance improvements including less rebooting (currently goes between 30-60 days before needing one) with future updates. We started with pre release versions of SmartEvent. In the short time (relative to the timeline and evolution of Windows ) I've been working with the system and tools, have found it to be invaluable, and evolving rapidly in the right direction.