Hi, I know from experience that it will work - but you should really get the mgmt interface of the SMO directly connected to the same subnet as the Management and log server etc...
There will/can be issues related to NAT, and also - if your management network in addition to contain management server, also has some esx hosts, a server or two...whatever else - that traffic will get issues.
In my last setup, the customer had a subnet where the management server was on a subnet that containd lots of "other stuff" to - due to design and historical configs, I ended ut adding an additional interface on the management server, and had my SMO connect to that, just to get it directly connected.