It depends on which blades you activate in the vs. You can't really make a general statement.
For the VS own VSX processes I see in practice about 1%-3% pervormance loss per instance.
If you use a large applinace, e.g. a 26000, this should not be a problem.
If you use a large applinace, e.g. a 26000, this should not be a problem.
For example, with 48 cores (48*100% = 4800% CPU performance) and 20 VS (2%*20 VS = 40% CPU performance) you lose 40% of 4800%. Is normally no problem.
It is similar with Maestro.
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