The very first packet of a TCP connection is a SYN with no other flags.
If we see the full TCP handshake, we can be sure the client actually initiated the connection with the server and the server acknowledged it:
Otherwise, it is possible some third party injected traffic.
Some reasons you might see these messages include:
- Long term TCP connection expires due to lack of activity (2 hours is the default)
- Asymmetric Routing
These checks are made for a reason and it is not generally recommended to disable these checks except in very specific circumstances for a limited period of time.