That error is essentially fancy way CP "tells" you that 3-way handshake is not completing. You need to run packet captures (tcpdump and fw monitor) to see whats is happening with the traffic.
Lets pretend (for this example) that src is 1.1.1.1 and dst is 2.2.2.2 and port is 443
You could run below:
tcpdump -enni any host 1.1.1.1 and host 2.2.2.2 and port 443
fw monitor -e "accept host(2.2.2.2) and port(443);"
fw monitor -F "1.1.1.1,0,2.2.2.2,443,0" -F "2.2.2.2,0,1.1.1.1,443,0"
idea is srcip,srcport,dstip,dstport,protocol...so you can have as many -F flags this way
Hope that helps.
Andy