The mentioned feature is not AntiSpam blade. AntiSpam is configured via old SmartDashboard. AntiSpam does checking blacklists, looking for spam etc.
You‘re showing the Mail features of ThreatPrevention. This checks mail messages for virusfiles, malicious attachments or malaicious links inside of mail messages. You have to enable MTA on the gateway to use this.
These are two different features for mail security which are differently configured.
Please show more details. What was disabled ? Which system shows the shown error message?
How about your mailflow?