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When making these decisions it's important to understand what these settings influence as relevant to what controls the gateway is enforcing. Provided below are some of the relevant resources for review:
SmartConsole R81.20 Help - Understanding Topology
sk108057: What does the box "Interface leads to DMZ" control in interface topology?
sk108057: How to configure the Protected Scope in Anti-Virus Settings for file downloads
sk64543: Topology and "Internet" object in Application and URL Filtering rule base
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