Yes, create what I call a "null" threat prevention profile with all five TP blades including IPS unchecked. Create a rule at the top of your Threat Prevention policy layer specifying the scanning boxes in the Protected Scope, and apply the null profile in the Action of that rule. Doing it this way instead of using a TP exception will make the traffic potentially eligible for full acceleration by SecureXL and substantially reduce load on the gateway. If you have more than one Threat Prevention policy layer (not likely), the null profile rule will need to be at the top of all TP layers.
Attend my online "Be your Own TAC: Part Deux" CheckMates event
March 27th with sessions for both the EMEA and Americas time zones