Leaving it off will I assume make your worker cores more vulnerable to getting saturated by elephant flows and thus decrease performance in that scenario, this is simply how traffic was handled in the early releases of R80.40 and R80.30 and earlier.
The pipeline paths only cover traffic in CPAS and PSL if Mux is enabled, so I would assume there would potentially be a slight performance decrease in those paths by leaving it off. Having Mux off should not affect traffic that is fully accelerated by SecureXL or F2F/slowpath traffic at all assuming my understanding is correct.
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