Hotfixes are individual patches that TAC may provide based on your specific environment.
Jumbo and Jumbo Hotfix Accumulators are effectively the same thing when comes to the patches and are collections of Hotfixes that TAC find releasings on a common/regular basis
The Take is the release version of the Jumbo/Jumbo Hotfix Accumulator
The Takes come in too flavours
Ongoing - This is a collection of Hotfixes that typically would install if instructed by TAC as in has a specific issue fixed that you are experiencing. Personally only install when TAC advise to do so. These will not appear in CPUSE as an available patch and you have to add manually to allow to download and install
General Availability - This is a collection that has gone through more testing and will be a Recommended Patch. As such this will appear under the Recommended Patches in CPUSE.
Is typically considered a reliable patch and should be available to install without issue. (Please note the use of the word should)
That is not to say that should not exercise full caution in terms of snapshots/backups/database revisions etc and testing when patching.
As with everything else then unless there is something in the Jumbo Take that specifically relates to your environment then no real need to rush out to patch so a lot of people will leave 1-2 weeks after a GA Take is released before implementing.