Appreciate your response. I read MDM, MUH v2 and IPv6 for Management interface are not supported. Security Gateway limitations mention about default kernel value and some commands. Please correct me if I missed the feature ID you are referring to.
Setup of (IPv6 LAN - Firewall - IPv6 LAN) end to end communication is working fine on Azure.
I redeployed everything locally with a 4600 appliance and seeing same behavior

I am wondering if any additional configuration is required for source NAT range to take effect.